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Uphononongo lwakutsha nje olupapashwe liqela lophando lwezenzululwazi laseKhanada lucebisa ukuba ii-cannabinoids zinokudlala indima ekuthinteleni nasekunyangeni i-COVID-19 kunye nexesha elide le-COVID.

Kuphononongo olubanzi, iqela lezazinzulu zaseCanada libonelela ngolwazi olunomdla kwindima enokubakho yee-cannabinoids ekulweni intsholongwane ye-COVID-19.Uphononongo, olunesihloko esithi "Cannabinoids kunye neNkqubo ye-Endocannabinoid kwi-SARS-CoV-2 yamandulo kunye nezigulana ezingapheliyo ze-COVID-19," yabhalwa nguCassidy Scott, uStefan Hall, uJuan Zhou, uChristian Lehmann kunye nabanye kwaye yapapashwa kwiJenali ye-SARS-CoV. -2″ imagazini.

Unyango lweKlinikhi.Ngokuhlalutya idatha ebanzi evela kwizifundo ezidlulileyo, ingxelo ixoxa ngendlela amacandelo esityalo se-cannabis esinokudlala ngayo indima ebalulekileyo ekuthinteleni ukuqala kwe-COVID-19 kunye nokunciphisa iziphumo zayo zexesha elide.Iziphumo zibonisa ukuba i-cannabinoids, ngakumbi ezo zikhutshwe kwisityalo se-cannabis, zinokunqanda ukungena kwentsholongwane kwiiseli, ukunciphisa uxinzelelo oluyingozi lwe-oxidative, kunye nokucinezela impendulo ehlala ibulala i-immune ebonwa kwiimeko ezinzima.Uphononongo lukwaqaqambisa indima enokubakho yee-cannabinoids ekujonganeni neempawu ezahlukeneyo eziqhubekayo ze-COVID-19 yexesha elide.

Ngokophononongo, i-cannabinoids inamandla okuthintela ukungena kwentsholongwane, ukunciphisa uxinzelelo lwe-oxidative kunye nokunciphisa isaqhwithi se-cytokine esihambelana nentsholongwane ye-COVID-19.Uphando lubonisa ukuba ngqoizicatshulwa ze-cannabinoidinokuthoba amanqanaba e-angiotensin-converting enzyme 2 (ACE2) kwizihlunu eziphambili, ngaloo ndlela ithintela iintsholongwane ukuba zingangeni kwiiseli zabantu.Abaphandi baqaphela ukuba oku kubalulekile xa kunikwa indima ye-ACE2 njengesango eliphambili lokungena ngentsholongwane.Ingxelo ikwaxoxa ngendima yee-cannabinoids ekujonganeni noxinzelelo lwe-oxidative, into ebalulekileyo kwi-pathogenesis ye-COVID-19.

Ngokuguqula ii-radicals zasimahla zibe ziifom ezingasebenziyo, i-cannabinoids ezifanaCBDinokunceda ukunciphisa iziphumo ezinobungozi zoxinzelelo lwe-oxidative kwiimeko ezinzima ze-COVID-19.Ngokophononongo, ii-cannabinoids zinokuba neziphumo eziluncedo kwizaqhwithi ze-cytokine, impendulo eqatha yokhuselo lomzimba olubangelwe yi-COVID-19.I-Cannabinoids ibonakaliswe ukuba iyasebenza ekunciphiseni i-cytokines evuthayo, iphakamisa amandla abo ekulawuleni iimpendulo ezinjalo zokuzivikela.

I-COVID ende ibhekisa kwimeko eyenzeka ngokwesiqhelo njenge-COVID-19 utshintsho ukuya kwinqanaba elingapheliyo.Uphando lubonisa amandla e-cannabinoids ekuphatheni iimpawu eziqhubekayo zokudakumba, ukuxhalaba, ukuphazamiseka kwengxaki emva kokuphazamiseka, ukulala, intlungu kunye nokulahlekelwa ngumdla.Inkqubo ye-endocannabinoid idlala indima ekusebenzisaneni kweenkqubo ezahlukeneyo ze-nervous, okwenza kube yinjongo yonyango lwezi mpawu ze-neuropsychiatric.

Uphononongo luphinde lwaphonononga iindlela ezahlukeneyo zokusetyenziswa kunye neentlobo ezahlukeneyo zeemveliso ze-cannabis ezisetyenziswa ngabathengi.Uphando lubonisa ukuba ukungeniswa nge-inhalation kunokuba nemiphumo emibi kubantu abaneemeko zokuphefumla, ukuchasana nemiphumo yayo yonyango."Ngelixa ukutshaya kunye ne-vaping zihlala zezona ndlela zikhethwayo kwizigulana ze-cannabis kuba ziqala ngokukhawuleza, izibonelelo ezinokubakho zonyango lwe-cannabinoid zinokulungiswa ziziphumo ezibi zokuphefumla kwimpilo yokuphefumla," batsho abaphandi.Uphononongo lubonisa "Izigulana ezisebenzisa i-cannabis vaporization ziba neempawu ezimbalwa zokuphefumla kunokutshaya kuba isixhobo se-vaporizer asiyitshisi i-cannabis ukuya kwinqanaba lokutsha."Ababhali bale ngxelo bagxininisa imfuneko yophando oluthe kratya kulo mmandla.Ngelixa iziphumo zokuqala zikhuthaza, zilumkisa ngokuba zizinto zokuqala kwaye ziphuma kwizifundo ezingangqalanga kwi-COVID-19.Ke ngoko, izifundo ezijolise ngakumbi kunye nezibanzi, kubandakanya nolingo lwezonyango, zibalulekile ukuba uqonde ngokupheleleyo indima kunye nokusebenza kakuhle kwee-cannabinoids ekunyangeni kwangethuba kunye nenqanaba elibukhali losulelo lwe-SARS-CoV-2.Ngaphezu koko, ababhali baxhasa uphando olunzulu ngakumbi kwi-pharmacology kunye nezicelo ezinokuthi zenzeke zonyango zenkqubo ye-endocannabinoid kwaye babongoze uluntu lwenzululwazi ukuba luhlolisise le ndlela.